Late-Life Depression: A Growing Concern
Did you know that late-life depression is a significant and often overlooked mental health issue affecting millions of older adults? With the global population aging rapidly, the prevalence of this condition is on the rise [i]. Characterized by persistent sadness, loss of interest, and changes in sleep, appetite, or energy levels, late-life depression can significantly impact quality of life.
The Unique Challenges of Late-Life Depression
Treating late-life depression presents unique challenges due to the frequent overlap with physical health problems, cognitive decline, social isolation, and the stigma associated with aging [ii]. The complexity of managing multiple health conditions and medications can lead to potential drug interactions and side effects. Furthermore, older adults may underreport symptoms or perceive them as a normal part of aging, complicating diagnosis and treatment. A comprehensive approach that addresses both the physical and emotional aspects of aging is essential for effective treatment.
TMS: A Promising Treatment
An evolving list of pharmacological interventions has been the primary treatment tool for major depressive disorder (MDD) for over 50 years. Yet, about 30% of patients with MDD do not respond well to pharmacotherapy including adults with late-life depression.[iii] This has led to a search for alternative and complementary treatment options.
Deep TMS: A Breakthrough for Older Adults
Transcranial Magnetic Stimulation (TMS) has emerged as a groundbreaking treatment for depression, including late-life depression. This non-invasive procedure uses magnetic fields to stimulate nerve cells in the brain, helping to alleviate depressive symptoms. Deep TMS, a more advanced form of TMS, has shown particular promise in older adults by targeting deeper brain regions [iv].
Studies have demonstrated that Deep TMS in patients with MDD 70 years and older found significant improvements in depressive symptoms.[v] These high response and remission rates in patients with treatment-resistant late-life depression demonstrate that Deep TMS is a safe, well-tolerated and effective treatment for this expanded age range of older adults offering hope to countless individuals who have struggled to find relief from the debilitating symptoms of depression.
Why this matters:
As our population ages, it is crucial to increase awareness of late-life depression and explore innovative treatment options like TMS to restore and improve the quality of life for countless older adults and their families.
There's more to uncover
Expand your knowledge of TMS by visiting our website. Discover in-depth details about the treatment process and find answers to frequently asked questions.
Sources:
[i] Almheiri, E.; Alhelali, A.; Abdelnaim, M.A.; Weber, F.C.; Langguth, B.; Schecklmann, M.; Hebel, T. Effectiveness of Repetitive Transcranial Magnetic Stimulation in the Treatment of Depression in the Elderly: A Retrospective Natural Analysis. J. Clin. Med. 2023, 12, 4748.
[ii] Reynolds, C.F., III; Lenze, E.; Mulsant, B.H. Assessment and treatment of major depression in older adults. Handb. Clin. Neurol. 2019,
[iii] Crown, W.H.; Finkelstein, S.; Berndt, E.R.; Ling, D.; Poret, A.W.; Rush, A.J.; Russell, J.M. The impact of treatment-resistant depression on health care utilization and costs. J. Clin. Psychiatry 2002, 63, 963–971
[iv] Roth, Y.; Munasifi, F.; Harvey, S.A.; Grammer, G.; Hanlon, C.A.; Tendler, A. Never Too Late: Safety and Efficacy of Deep TMS for Late-Life Depression. J. Clin. Med. 2024, 13, 816.
[v] Zhang, M.; Mo, J.; Zhang, H.; Tang, Y.; Guo, K.; Ouyang, X.; Huang, L.; Zhong, X.; Ning, Y. Efficacy and tolerability of repetitive transcranial magnetic stimulation for late-life depression: A systematic review and meta-analysis. J. Affect. Disord. 2023, 323, 219–231
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